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Isle of Palms, South Carolina is the perfect seaside vacation destination for a number of reasons. Our vacation homes in Isle of Palms SC are also known to be the most luxurious in all of the Charleston area, providing more than ample space and a private place to share joy-filled experiences with friends and family members. Our Isle of Palms vacation rentals range from four to eleven bedrooms in size, with enormous bedrooms that each have their own lavish bathroom—meaning that the members of your travelling party will want for nothing in terms of space, privacy, and luxury.